Targeting LIM kinases in taxane resistant tumors
نویسندگان
چکیده
منابع مشابه
Targeting LIM kinases in taxane resistant tumors
Microtubule stabilizing drugs such as taxanes have proven fairly effective for treating solid tumors, but the mechanism by which these drugs treat cancer is still unsolved. Intratumor imaging, showing that the cell proliferation rate is low in many chemosensitive human cancers, has challenged the dogma that the cytotoxicity of such compounds is the result of their effect on rapidly dividing cel...
متن کاملCancer Therapy: Preclinical Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Purpose: Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. Experimental Design:Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapyresistant tumor...
متن کاملPreclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors.
PURPOSE Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. EXPERIMENTAL DESIGN Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapy-resistant tum...
متن کاملLIM kinases: cofilin and beyond
LIM kinases are common downstream effectors of several signalization pathways and function as a signaling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. These last 10 years, several reports indicate that the functions of LIM kinases are more extended than initially described and, specifically, that LIM kinases also control microtubule dynami...
متن کاملTargeting LIM kinase in cancer and neurofibromatosis
Neurofibromatosis type 1 is among the most common inherited diseases, affecting 1 in 3500 individuals. The phenotype of this autosomal-dominant disorder is highly variable and can be mild or severe. Symptoms might include café-au-lait spots, low intelligence, specific learning difficulties and behavioral problems, bone deformations, and various neurological syndromes. These patients are prone t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.10816